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KMID : 0882420120830030385
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Korean Journal of Medicine
2012 Volume.83 No. 3 p.385 ~ p.389
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A Case of Primary Effusion Lymphoma in a Patient with Chronic Kidney Disease
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Kim Mi-Yeon
Han Sang-Hoon
Yu Jung-Re
Jeong Woo-Seong
Kim Hyun-Woo
Lee Jae-Chun
Hyun Chang-Lim
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Abstract
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Human herpes virus-8 (HHV-8)-negative primary effusion lymphoma (PEL) is frequently observed in patients with chronic liver disease. We describe herein a case of PEL in a patient with chronic kidney disease. A 59-year-old woman presented with dyspnea. The patient had a history of uncontrolled pleural effusion. The pleural effusion revealed a malignant cell-dominant exudate. Serological tests were negative for human immunodeficiency virus (HIV). Initial chest and abdomen computed tomography showed bilateral pleural effusion; however, no evidence of a tumor mass or lymph node enlargement was found. A malignant lymphoma of diffuse large B-cell type was confirmed by pleural fluid cytology. Immunohistochemical staining of malignant cells was negative for HHV-8. She was treated with rituximab and CHOP (cyclophosphamide, adriamycin, vincristine, prednisolone) chemotherapy. We report a case of PEL in a patient with chronic kidney disease that may be a plausible predisposing factor for HHV-8-negative PEL.
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KEYWORD
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Chemotherapy, Diffuse large B cell lymphoma, Primary effusion lymphoma
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